Wednesday, 10 March 2010

[P416.Ebook] Ebook Partners in Power: The Clintons and Their America, by Roger Morris

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Partners in Power: The Clintons and Their America, by Roger Morris

In the finest tradition of investigative journalism, Roger Morris goes far behind the public facade to expose the inner politics, personal passions, and gathering moral compromise that marked the rise of Bill and Hillary Clinton. After three years of painstaking research and hundreds of interviews, the author, a prizewinning historian, reveals in riveting detail the untold secrets of one of the most ambitious partnerships in modern politics.

Starting with the roadhouses and mob-ruled politics of the old South, Partners in Power draws the reader into the dramatic, seamy, largely hidden world that gave rise to - and explains - the Clinton presidency. Morris weaves together three essential themes: the parallel lives and tortured relationship of the Clintons personally; the essence of the bipartisan misrule that is Washington, D.C. (how the collusive culture of our national government defeats change); and, most telling, the behind-the-scenes story of the making of a president in a world where corrupting money and favors flow freely and the tyranny of wealthy interests and their captive politicians mock democracy.

Beyond myriad scandals - whether shady bond, banking, and commodity "deals"; the Whitewater imbroglio; abuses of power in covering up sexual infidelities; document "shredding parties"; the Vince Foster tragedy; or a multibillion- dollar Arkansas gunrunning and drug-smuggling ring implicating the Colombian cartel, the CIA, organized crime, and two Republican presidents as well as a Democratic governor and future president - Morris's evocation of a climb to power, is the most candid, revealing, and courageous portrait ever drawn of a sitting president. In its magisterial analysis of a political system gone lethally wrong, Partners in Power offers a brilliant perspective on a government and ultimately a people. As a dual biography of a first couple, it is without precedent in political literature.

  • Sales Rank: #413807 in Books
  • Brand: Henry Holt and Company
  • Published on: 1996-06
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.75" h x 6.75" w x 1.75" l,
  • Binding: Hardcover
  • 526 pages
Features
  • Great product!

Amazon.com Review
Absent a royal family, the American people have developed a thirst for subjects for gossip from on high. In Bill and Hillary Clinton, they have them. Roger Morris charges the first family with misdeeds committed while upon the throne in Arkansas: Bill taking money from Whitewater partner James McDougal; Hilary using well-connected brokers to win fabulous returns on her investments; the governor's affairs; and their friendship with a drug-dealing bond daddy, to name a few. Those after the dirt on the Clintons will love this wheelbarrow full of it.

From Library Journal
Morris, author of National Book Award nominee Richard Milhous Nixon: The Rise of an American Politician (LJ 12/89), has written arguably the most damning indictment of the Clintons to date. In addition to being the author of several well-received books, Morris was a highly respected public servant, working for Dean Acheson, Lyndon Johnson, Walter Mondale, and Richard Nixon and resigning from the National Security Council over the Cambodian invasion during the Nixon administration. Bill and Hillary Clinton are viewed as emblematic of a rotten political system that has sold out the interests of its citizens for the financial support of corrupt monied interests. Arkansas was a fertile training ground in no small part because of its few wealthy corporations, including Tyson Foods, Stephens, Inc., and Wal-Mart. The image of Bill Clinton as a moderate, public-oriented leader rings hollow to Morris. Hundreds of understandably confidential interviews present a sordid tale of a governor who allegedly sold his political soul to the Arkansas power structure. The Clintons, according to Morris, handsomely profited from Whitewater at the expense of the people the governor swore to protect. The harrowing tales of cocaine-sniffing toga parties pale in comparison with Clinton's alleged ties to organized crime, the Iran-Contra debacle, and drug smuggling from Mena, Arkansas. No one should come away from this book happy; complicity in the government's breakdown includes and transcends both parties. Clinton supporters will be despondent. An instant best seller that will stir considerable discussion and should be purchased by all public libraries.?Karl Helicher, Upper Merion Township Lib., King of Prussia, Pa.
Copyright 1996 Reed Business Information, Inc.

Review
We will be hearing more of Mr. Morris' material.... Republicans will no doubt take it up for partisan reasons and the press, some of which is beginning to feel it gave the Clintons a free ride in 1992, may be looking to make amends. -- The New York Times Book Review, Richard Brookhiser

Most helpful customer reviews

5 of 5 people found the following review helpful.
Excellent books - digs deep on the Clintons. Buy it!
By Robert P. Morrow
Roger Morris is a very credible author. He and his wife Sally Denton put out fabulous work on every topic they research. And the inside scoop on Bill Clinton is no different.

Roger Morris was one of the first to find out that Bill Clinton had been recruited into the CIA when he was at Oxford - to inform on his anti-war buddies. The CIA is the one who paid for Clinton's trips into Eastern Europe. Cord Meyer of the CIA was the one who recruited Clinton and he reported as much to GOP uber insider Jack Wheeler.

Roger Morris also came across another one of Bill Clinton's vicious sexual assaults. Not the Juanita Broaddrick rape of 1978, but yet another vicious sexual assault in which Clinton - YET AGAIN - bites a woman victim and sexually assaults her. Clinton later appointed this woman's husband to the Arkansas Real Estate Commission - probably to keep them quiet.

"A young woman lawyer in Little Rock claimed that she was accosted by Clinton while he was attorney general and that when she recoiled he forced himself on her, biting and bruising her. Deeply affected by the assault, the woman decided to keep it all quiet for the sake of her own hard-won career and that of her husband. When the husband later saw Clinton at the 1980 Democratic Convention, he delivered a warning. 'If you ever approach her,' he told the governor, 'I'll kill you.' Not even seeing fit to deny the incident, Bill Clinton sheepishly apologized and duly promised never to bother her again." [Partners in Power, page 238]

Roger Morris interviewed the anonymous couple who are socially prominent in Arkansas in late 1993 and again in early 1994.

Buy this book. Lots of great info in it!

2 of 3 people found the following review helpful.
A well written book about Hillary and Bill: Partners in power, partners in sleaze.
By Happy Poet
Partners in power, partners in sleaze. How anyone could think of voting for Hillary is a mind damaging thought. Read it and learn,

1 of 1 people found the following review helpful.
A juicy, captivating examination of our former leader
By Dustin Augustine DeMille, Sir Dicequa of Angelica
"Partners in Power" is an inside look at the lives of our former leader and his wife, President Bill Clinton and Hillary Clinton. The book is an intelligent, interesting reading, even shocking and surprising at times. We get the juicy, inside scoop on what went on behind the scenes. Bill's childhood and political career are thoroughly examined here. The author is clearly very educated as his prose is intensely thought-provoking. Opinions are abundant here, and he actually criticizes Clinton from the left. A brief synopsis of modern political history is interwoven in the book. I learned an enormous amount from reading this book, as it is full of interesting information. For example, apparently Clinton had drugs and hookers in the Arkansas Governor's Mansion, with his security helping to keep things secret. It is very funny at times too. This is one of the best political books I have read.

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Monday, 8 March 2010

[G293.Ebook] Free PDF Tastes and Temptations: Food and Art in Renaissance Italy

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Tastes and Temptations: Food and Art in Renaissance Italy

  • Published on: 1600
  • Binding: Paperback

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[T787.Ebook] PDF Ebook Plaid Skirt Confessions, by Selena Kitt

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Plaid Skirt Confessions, by Selena Kitt

From bestselling and award-winning author Selena Kitt - Over a Million Books Sold!
 
Leah and Erica have been best friends and have gone to the same Catholic school since just about forever. Leah spends so much time with the Nolans--just Erica and her handsome father now, since Erica's mother died--that she's practically part of the family. When the girls find something naughty under Mr. Nolan's bed, their strict, repressive upbringing makes it all the more exciting as they begin their sexual experimentation. Leah's exploration presses deeper, and eventually she finds herself in love for the first time, torn between her best friend and her best friend's father.

NOTE TO READERS: This story appeared in another, now rather infamous book of mine (UNDER MR. NOLAN'S BED). This tale is a slightly less naughty, but no less sexy re-telling of those events--updated and redressed for your reading pleasure with an ending that may leave you a little more satisfied.


Warnings: This title contains erotic situations, lesbian sex, sex toys, and also makes mention of pornography, salmon, amusement parks, chocolate covered strawberries, brownies (as well as girl scouts), plaid skirts, naughty uses for confessionals and some sacrilegious humor.
 
The Nolan Trilogy

  • Temptation
  • Confession

  • Grace
  • Related Titles
    • Under Mr. Nolan's Bed (Original)
     
    EXCERPT:
    "I saw you, Mr. Nolan."

    His jaw dropped and he looked at me, incredulous. "Saw me?"

    "The night you came into the bathroom. Do you remember that?"

    Glancing at him, I saw him nod, his face pale again.

    "I watched you," I admitted, my voice almost a whisper. "Touching yourself."

    "Oh Christ," he whispered, closing his eyes.

    "I can't stop thinking about it," I confessed. "Seeing you stroking yourself while you watched that man on the screen fuck those two girls..."

    His eyes met mine, and I saw the shock in them at my language, but there was something else too, that wasn't just shock. I'd seen it before, in the kitchen when he'd looked up my skirt, and a moment ago too, when he'd walked in and caught me masturbating.

    "I can't stop thinking about you," I whispered, moving my hand up his thigh, high enough to feel that he was hard. I was encouraged by that, and the alcohol made me feel more free, like I'd drunk some liquid courage.

    "Leah, I know this kind of thing can be confusing." He took my hand and put it in my lap with a shaky sigh.

    "I'm not confused," I insisted, sliding down to the floor and kneeling between his legs. He shook his head, but I wrapped my arms around his waist, pressing my cheek against his crotch and nuzzling there.

    • Sales Rank: #927841 in Books
    • Brand: Brand: Excessica
    • Published on: 2010-12-26
    • Original language: English
    • Number of items: 1
    • Dimensions: 8.00" h x .42" w x 5.25" l, .44 pounds
    • Binding: Paperback
    • 184 pages
    Features
    • ISBN13: 9781609824990
    • Condition: New
    • Notes: BRAND NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!

    From the Author
    FREEBIES from Selena Kitt!

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    Don't forget to leave a REVIEW! Please take a moment to leave your opinion about this book! Readers and writers rely on reviews! Your opinion will help other readers make their future purchasing decisions in regards to ebooks. Remember to make your vote count!

    About the Author
    Selena Kitt is a bestselling and award-winning author of erotic romance fiction and erotica. OVER A MILLION BOOKS SOLD! Her writing embodies everything from the spicy to the scandalous.
     
     
    When she's not pawing away at her keyboard, Selena runs an innovative publishing company (excessica.com). She does bellydancing and photography, and she loves four poster beds, tattoos, voyeurism, blindfolds, velvet, baby oil, the smell of leather, and playing kitty cat. 
     
    Her books EcoErotica (2009), The Real Mother Goose (2010) and Heidi and the Kaiser (2011) were all Epic Award Finalists. Her gay male romance, Second Chance, won the Epic Award in Erotica in 2011. Her FREE story, Connections, was one of the runners-up for the 2006 Rauxa Prize, given annually to an erotic short story of "exceptional literary quality," out of over 1,000 nominees, where awards are judged by a select jury and all entries are read "blind" (without author's name available.)
     
    She can be reached on her website at selenakitt.com

    Most helpful customer reviews

    3 of 4 people found the following review helpful.
    Warning: This is HOT! It will melt your kindle!
    By NReads
    WOW! This novel was oh-so-very hot & naughty. In Plaid Skirt Confessions, the reader dives into the world of taboo involving best friends Leah, Erica, & Mr. Nolan (Erica's father). Leah and Erica have been best friends and have gone to the same Catholic school since they were kids. Leah spends a lot of time with the Nolans which is now just Erica and her handsome father since Erica's mother died. When the girls find something naughty under Mr. Nolan's bed, their strict, repressive upbringing makes it all the more exciting as they begin their sexual experimentation & it is HOT! Leah's exploration presses deeper, and eventually she finds herself in love for the first time, torn between her best friend and her best friend's father.

    I've read a lot of erotica & hands down, Selena Kitt is probably up there in the number one spot! She is in a category of her own. Moreover, she is definitely the cream of the crop in the erotic fiction genre! Ms. Kitt definitely turned up the heat and steam factor in this novella! Her writing flowed smoothly & along with vivid descriptions, it is enough for the reader to visualize scenes & get your juices flowing ;)

    Overall, this novella was very, very HOT! Thus, this is not for the faint of the heart. Highly recommend if you're into erotica!

    *WARNING: ADULT READING MATERIALS: EXPLICIT SEX, M/F & F/F ACTION, & WHOLE LOT OF NAUGHTINESS!

    1 of 1 people found the following review helpful.
    book
    By Mo
    ok

    0 of 0 people found the following review helpful.
    Five Stars
    By David L Cohan
    awesome

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    [Y724.Ebook] PDF Download Crucified, by Michael Slade

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    Crucified, by Michael Slade

    A new thriller - Germany: a bulldozer on a construction site uncovers the remains of a Second World War bomber and so begins a treacherous international journey from the crucifixionof Jesus at Golgotha to modern archaeological discoveries. Lawyer/historian Wyatt Rook and Liz Hannah must solve a series of whodunitsto unravel the Judas puzzle. Blocking them at every turn isthe Legionary of Christ, a crusader backed by a secret inquisition that will stop at nothing to make sure the Judas puzzle remains unsolved.

    • Sales Rank: #3027235 in Books
    • Brand: Brand: Severn House Publishers
    • Published on: 2008-09-01
    • Original language: English
    • Number of items: 1
    • Dimensions: 8.42" h x 1.34" w x 5.84" l,
    • Binding: Hardcover
    • 333 pages
    Features
    • ISBN13: 9780727866523
    • Condition: New
    • Notes: BRAND NEW FROM PUBLISHER! 100% Satisfaction Guarantee. Tracking provided on most orders. Buy with Confidence! Millions of books sold!

    From Publishers Weekly
    The discovery more than 60 years later of the wreckage of a British bomber that crashed in Germany in 1944 triggers a hunt for connections to Christ's crucifixion, the Crusades and the Spanish Inquisition in this middling religious thriller from Slade (Kamikaze). Wyatt Rook, an American writer who specializes in books and TV documentaries that dig up dirt about recent history, agrees to help a sexy young British researcher, Liz Hannah, look into the case of the crashed plane (of which her grandfather was a crew member). The complicated trail takes the pair from England to Germany, where a plot involving Churchill and a Nazi traitor called Judas began, and then to Golgotha. Meanwhile, the Vatican's Art Historian is worried (If the resurrected bomber yields a map to the Judas package, Christendom might be rocked to its two-thousand-year-old foundations). Those with an insatiable appetite for Da Vinci Codeknockoffs will be most rewarded. (Oct.)
    Copyright � Reed Business Information, a division of Reed Elsevier Inc. All rights reserved.

    Most helpful customer reviews

    9 of 10 people found the following review helpful.
    Flight of faith
    By Bawlmer Guy
    [Note: This review based on the Canadian trade paperback edition]

    For many years after my introduction to Michael Slade during the mid-80s, it was tempting to compare successive Special X novels to Slade's first two, Headhunter and Ghoul. This made for a somewhat unsatisfying progression despite some excellent stories. The antidote was to appreciate the merits of each novel on its own. Eventually it became clear that Slade has little interest in being nailed down to any formula, genre, or subject matter, except perhaps for his love of mystery, history, and inventive mayhem. Even so prepared, I was stunned to learn that Slade has offered in his thirteenth novel a thrilling departure from the Special X series.

    Crucified is sweet torture for the reader who seeks an answer to the still-hanging "who lives, who dies" question at the end of Kamikaze, the previous Slade novel. It's also a superb example of Slade's ability to link seemingly disparate elements--to reveal what they are would spoil the fun, but they exceed the jaw-dropping connections (among Chinese pharmaceuticals, General Custer, and the legendary Sasquatch) found in Slade's novel Cutthroat. Yet the connections are quite logical; Slade has simply looked deeply enough into history to find them. On top of it all, Crucified entails some interesting twists on the locked-room puzzle found in some Golden Age mysteries.

    Wyatt Rook, an author who specializes in Second World War plots, probes the crash site of a British bomber downed over Germany in 1944. As he tries to learn the fates of missing airmen, Rook runs afoul of murderous conspirators who are determined to acquire religious artifacts on behalf of the Vatican.

    Crucified includes some fine, realistic exposition of Royal Air Force bomber crews' daily routines. The passages seem to stem from first-hand interviews. If so, it's commendable that Slade has saluted war heroes from another era before they pass on. Tight, smooth, and engrossing throughout, Crucified is the work of a novelist moving onward and upward. Even far from the familiar ground of Special X, Slade flies high, straight, and true. It's a most welcome adventure.

    1 of 1 people found the following review helpful.
    The 13th offering from Michael Slade... Without Special X?!
    By PohlSE
    Michael Slade's 13th thriller is a true departure from what made him one of the best crime fiction writers; The Special X division of the RCMP. Instead Slade introduces us to a new cast of characters for Crucified, and what do we the readers get? Final, unquestionable proof that Michael Slade is THE best crime fiction writer of the past half century!

    Lawyer/Historian Wyatt Rook is drawn into an investigation by Liz Hannah where he must deal with a series of locked room mysteries, whodunits, and biblical puzzles that build to a crescendo with the ultimate locked room mystery: The Judas Puzzle.

    This is a fascinating book that spans the globe and spans history from two thousand years ago, WWII Germany, and the present day, and continues at a break neck pace until it spirals to the dizzying conclusion.

    A great, page turning, thriller that is a must read.

    4 of 4 people found the following review helpful.
    A New Character . . . .
    By J. S.
    As a devotee of all things Slade . . . I was interested in reading this latest offering . . . and I was not disappointed. As usual, my friend Slade brings history into the story line . . . and that prompted me to want to read more on the subjects mentioned. And with the creation of a new character in Wyatt Rook . . . the creative juices will be renewed for future adventures. In my opinion it takes a lot to keep those juices flowing . . . as evidenced by the change over time in the books of Dean Koontz and Steven King and others who have continued to create and develop characters that I truly care about and want to read more about. Those are the kinds of authors I ENJOY . . . and kudos to Slade for continuing the cause!!!

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    Saturday, 27 February 2010

    [V452.Ebook] Get Free Ebook Mutual Fund Industry Handbook : A Comprehensive Guide for Investment Professionals, by Lee Gremillion

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    Mutual Fund Industry Handbook : A Comprehensive Guide for Investment Professionals, by Lee Gremillion

    "The Mutual Fund Industry Handbook is a remarkably important work . . . I am profoundly impressed by the broad and comprehensive sweep of information and knowledge that this book makes available to industry participants, college and business school students, and anyone else with a serious interest in this industry."
    -- From the Foreword by John C. Bogle President, Bogle Financial Markets Research Center Founder and former chief executive, The Vanguard Group

    A Foreword by John C. Bogle, founder of The Vanguard Group and one of the most respected leaders in the mutual fund industry, sets the stage for this authoritative book that explains the complexities of the phenomenal industry in simple terms.

    Investors like the fact that mutual funds offer professional management, easy diversification, liquidity, convenience, a wide range of investment choices, and regulatory protection. Mutual Fund Industry Handbook touches on all of those features and focuses on the diverse functions performed in the day-to-day operations of the mutual fund industry. You'll learn about:

    • Front-office functions-analysis, buying, and selling.
    • Back-office functions, including settlement, custody, accounting, and reporting.
    • Commission structures-front-end loads, back-end loads, or level loads.
    • The various fund categories used by the Investment Company Institute, Morningstar, and Lipper.
    • The roles played by fund managers, investment advisors, custodial banks, distributors, transfer agents, and other third-party service providers.

    If you want a definitive reference on the mutual fund industry, this is the book for you.

    • Sales Rank: #414658 in Books
    • Published on: 2005-08-26
    • Original language: English
    • Number of items: 1
    • Dimensions: 9.30" h x 1.20" w x 6.30" l, 1.40 pounds
    • Binding: Hardcover
    • 381 pages

    From the Inside Flap
    A behind-the-scenes look at the mutual fund industry

    With more than 8,000 funds, more than $8 trillion in assets, and more than 87 million individual investors at the end of 2004, mutual funds—professionally managed pooled investment vehicles that give people the opportunity to participate in the securities market without having to become money managers—are very popular.

    This book focuses on open end funds, and gives you a comprehensive inside look at the mutual fund industry, including real-life examples of how specific functions are performed at various firms. You'll explore industry history and structure, investment management, portfolio operations, accounting, auditing, legal compliance, customer service, distribution, globalization, and e-commerce. You'll also learn about the cost of various mutual fund operations—both to the fund companies and to investors.�

    Mutual Fund Industry Handbook does not provide information about how to select mutual funds or delve into specific funds or categories of funds. Rather, it describes every facet of mutual fund operations in an accessible and easy-to- understand manner. It also objectively addresses controversial topics, such as the fees that funds charge investors, disclosure requirements, advertising, active versus passive management, responsibilities of fund directors, and recent scandals, including illegal late trading and market timing. Mutual Fund Industry Handbook concludes with a discussion of trends and conditions that can impact the industry.

    Whether you're an investment professional looking to improve your mutual fund knowledge or an investor who wants to understand what goes on behind the scenes throughout the mutual fund industry, this is the resource for you.

    From the Back Cover
    Praise for the Mutual Fund Industry Handbook

    "The Mutual Fund Industry Handbook is a remarkably important work . . . I am profoundly impressed by the broad and comprehensive sweep of information and knowledge that this book makes available to industry participants, college and business school students, and anyone else with a serious interest in this industry."
    —From the Foreword by John C. Bogle President, Bogle Financial Markets Research Center Founder and former chief executive, The Vanguard Group

    A Foreword by John C. Bogle, founder of The Vanguard Group and one of the most respected leaders in the mutual fund industry, sets the stage for this authoritative book that explains the complexities of the phenomenal industry in simple terms.

    Investors like the fact that mutual funds offer professional management, easy diversification, liquidity, convenience, a wide range of investment choices, and regulatory protection. Mutual Fund Industry Handbook touches on all of those features, but it also focuses on the diverse functions performed in the day-to-day operations of the mutual fund industry. You'll learn about:

    • Front-office functions—analysis, buying, and selling
    • Back-office functions, including settlement, custody, accounting, and reporting
    • Commission structures—front-end loads, back-end loads, or level loads
    • The various fund categories used by the Investment Company Institute, Morningstar, and Lipper
    • The roles played by fund managers, investment advisors, custodial banks, distributors, transfer agents, and other third-party service providers

    If you want a definitive reference on the mutual fund industry, this is the book for you.

    About the Author
    LEE GREMILLION is a former partner at PricewaterhouseCoopers where he provided operations and systems expertise to many U.S. mutual funds, insurance companies, investment managers, pension administrators, and banks.� He earned a doctoral degree from Harvard Business School and was professor of management information systems at Indiana University and Boston University. Dr. Gremillion worked for IBM and The Colonial Group, Inc., before joining PricewaterhouseCoopers.

    THE BOSTON INSTITUTE OF FINANCE (BIF) (www.bostonifi.com) develops and distributes multimedia and interactive learning solutions for professionals in the financial services industry. BIF possesses the largest digital repository of training material in the industry and manages the certification and training programs of thousands of corporate and individual learners in the United States and around the world.

    THE NATIONAL INVESTMENT COMPANY SERVICE ASSOCIATION (NICSA) is a not-for-profit trade association serving the operations sector of the mutual fund industry worldwide. NICSA provides leadership, education programs, and information exchanges to its members, which consists of over 400 companies worldwide.

    Most helpful customer reviews

    0 of 0 people found the following review helpful.
    Good comprehensive information on mutual funds
    By mike
    A good comprehensive outline of how mutual funds work, with references to sources for further information. Ideally, every mutual fund investor should read this. Includes interesting side stories on different aspects of mutual funds. Fairly clearly written.

    9 of 11 people found the following review helpful.
    Most well-written book you'll probably find
    By John Yang
    I needed a good resource to learn about the securities and MF industry. This book is by far better written and more accessible than most other books - much better than Pozen's book on MFs and other popular books like "after the trade is made". Actually was enjoyable to read with great explanations and interesting sidebars. Very comprehensive with good diagrams.

    5 of 5 people found the following review helpful.
    Complementary Book
    By Michael Mills
    Start a Successful Mutual Fund by Melinda Gerber lists this book as a recommended read. It definitely complements her book. While hers includes the costs and steps to start a mutual fund (and how to choose service providers), this one shows how a mutual fund's service providers work together. This book is for anyone interested in learning about what goes on to support a mutual fund.

    See all 10 customer reviews...

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    Tuesday, 16 February 2010

    [O626.Ebook] Ebook Free Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids, by Richard Durbin, Sean R. Eddy, Anders Krogh, Graeme Mi

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    Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids, by Richard Durbin, Sean R. Eddy, Anders Krogh, Graeme Mi

    Probablistic models are becoming increasingly important in analyzing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analyzing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it is accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time presents the state of the art in this new and important field.

    • Published on: 2012-09-05
    • Original language: English
    • Binding: Printed Access Code

    Review
    "The book is amply illustrated with biological applications and examples." Cell

    "...successfully integrates numerous probabilistic models with computational algorithms to solve molecular biology problems of sequence alignment...an excellent textbook selection for a course on bioinformatics and a very useful consultation book for a mathematician, statistician, or biometrician working in sequence alignment." Bulletin of Mathematical Biology

    "This is one of the more rewarding books I have read within this field. My overall evaluation is that this book is very good and a must read for active participants in the field. In addition, it could be particularly useful for molecular biologists" Theoretical Population Biology

    Most helpful customer reviews

    43 of 46 people found the following review helpful.
    Excellent overview of probabilistic computational biology
    By Dr. Lee D. Carlson
    This book is a very well written overview to hidden Markov models and context-free grammar methods in computational biology. The authors have written a book that is useful to both biologists and mathematicians. Biologists with a background in probability theory equivalent to a senior-level course should be able to follow along without any trouble. The approach the author's take in the book is very intuitive and they motivate the concepts with elementary examples before moving on to the more abstract definitions. Exercises also abound in the book, and they are straightforward enough to work out, and should be if one desires an in-depth understanding of the main text. In addition, there is a software package called HMMER, developed by one of the authors (Eddy) that is in the public domain and can be downloaded from the Internet. The package specifically uses hidden Markov models to perform sequence analysis using the methods outlined in the book.
    Probabilistic modeling has been applied to many different areas, including speech recognition, network performance analysis, and computational radiology. An overview of probabilistic modeling is given in the first chapter, and the authors effectively introduce the concepts without heavy abstract formalism, which for completeness they delegate to the last chapter of the book. Bayesian parameter estimation is introduced as well as maximum likelihood estimation. The authors take a pragmatic attitude in the utility of these different approaches, with both being developed in the book.
    This is followed by a treatment of pairwise alignment in Chapter Two, which begins with substitution matrices. They point out, via some exercises, the role of physics in influencing particular alignments (hydrophobicity for example). Global alignment via the Gotoh algorithm and local alignment via the Smith-Waterman algorithm, are both discussed very effectively. Finite state machines with accompanying diagrams are used to discuss dynamic programming approaches to sequence alignment. The BLAST and FASTA packages are briefly discussed, along with the PAM and BLOSUM matrices.
    Hidden Markov models are treated thoroughly in the next chapter with the Viterbi and Baum-Welch algorithms playing the central role. HIdden Markov models are then used in Chapter 4 for pairwise alignment. State diagrams are again used very effectively to illustrate the relevant ideas. Profile hidden Markov models which, according to the authors are the most popular application of hidden Markov models, are treated in detail in the next chapter. A very surprising application of Voronoi diagrams from computational geometry to weighting training sequences is given.
    Several different approaches, such as Barton-Sternberg, CLUSTALW, Feng-Doolittle, MSA, simulated annealing, and Gibbs sampling are applied to multiple sequence alignment methods in Chapter 6. It is very well written, with the only disappointment being that only one exercise is given in the entire chapter. Phylogenetic trees are covered in Chapter 7, with emphasis placed on tree building algorithms using parsimony. The next chapter discusses the same topic from a probabilistic perspective. This to me was the most interesting part of the book as it connects the sequence alignment algorithms with evolutionary models.
    The authors switch gears starting with the next chapter on transformational grammars. It is intriguing to see how concepts used in compiler construction can be generalized to the probabilistic case and then applied to computational biology. The PROSITE database is given as an example of the application of regular grammars to sequence matching. This chapter is fascinating reading, and there are some straightforward exercises illustrating the main points.
    The last chapter covers RNA structure analysis, which introduces the concept of a pseudoknot. These are not to be confused with the usual knot constructions that can be applied to the topology of DNA, but instead result from the existence of non-nested base pairs in RNA sequences. The authors discuss many other techniques used in RNA sequence analysis and take care to point out which ones are more practical from a computational point of view. Surprisingly, genetic algorithms and algorithms based on Monte Carlo sampling are not discussed in the book, but the authors do give references for the interested reader.
    The best attribute of this book is that the authors take a pragmatic point of view of how mathematics can be applied to problems in computational biology. They are not dogmatic about any particular approach, but instead fit the algorithm to the problem at hand.

    24 of 26 people found the following review helpful.
    Fantastic Descriptions of Probabilistic Sequence Algorithms
    By Bob Carpenter
    I picked up this book at the recommendation of a number of colleagues in computational linguistics and speech processing as a way to find out what's going on in biological sequence analysis. I was hoping to learn about applications of the kinds of algorithms I know for handling speech and language, such as HMM decoding and context-free grammar parsing, to biological sequences. This book delivered, as recommended.
    As the title implies, "Biological Sequence Analysis" focuses almost exlusively on sequence analysis. After a brief overview of statistics (more a reminder than an introduction), the first half of the book is devoted to alignment algorithms. These algorithms take pairs of sequences of bases making up DNA or sequences of amino acids making up proteins and provide optimal alignments of the sequences or of subsequences according to various statistical models of match likelihoods. Methods analyzed include edit distances with various substitution and gapping penalties (penalties for sections that don't match), Hidden Markov Models (HMMs) for alignment and also for classification against families, and finally, multiple sequence alignment, where alignment is generalized from pairs to sets of sequences. I found the section on building phylogenetic trees by means of hierarchical clustering to be the most fascinating section of the book (especially given its practical application to classifying wine varietals!). The remainder of the book is devoted to higher-order grammars such as context-free grammars, and their stochastic generalization. Stochastic context-free grammars are applied to the analysis of RNA secondary structure (folding). There is a good discussion of the CYK dynamic programming algorithm for non-deterministic context-free grammar parsing; an algorithm that is easily applied to finding the best parse in a probabilistic grammar. The presentations of the dynamic programming algorithms for HMM decoding, edit distance minimization, hierarchical clustering and context-free grammar parsing are as good as I've seen anywhere. They are precise, insightful, and informative without being overly subscripted. The illustrations provided are extremely helpful, including their positioning on pages where they're relevant.
    This book is aimed at biologists trying to learn about algorithms, which is clear from the terse descriptions of the underlying biological problems. The technical details were so clear, though, that I was able to easily follow the algorithms even if I wasn't always sure about the genetic applications. After studying some introductions to genetics and coming back to this book, I was able to follow the application discussions much more easily. This book assumes the reader is familiar with algorithms and is comfortable manipulating a lot of statistics; a gentler introduction to exactly the same mathematics and algorithms can be found in Jurafsky and Martin's "Speech and Language Processing". For biologists who want to see how sequence statistics and algorithms applied to language, I would suggest Manning and Schuetze's "Foundations of Statistical Natural Language Processing". Although it is much more demanding computationally, more details on all of these algorithms, as well as some more background on the biology, along with some really nifty complexity analysis can be found in Dan Gusfield's "Algorithms on Strings, Trees and Sequences".
    In these days of fly-by-night copy-editing and typesetting, I really appreciate Cambridge University Press's elegant style and attention to detail. Durbin, Eddy, Krogh and Mitchison's "Biological Sequence Analysis" is as beautiful and readable as it is useful.

    24 of 28 people found the following review helpful.
    I SECOND THAT EMOTION
    By A Customer
    This is that rarest of rare: an intro-level, multi-authored monograph which is thorough, internally consistent, and a joy to read. Unlike the reviewer above, although not the first book I read on the subject, had it been so, I could have saved myself a great deal of time. As an introductory work it is simply unparalleled. In view of the rate of information growth in the field, this reader thinks it deserves to be amended annually, not merely reprinted periodically. The authors and editors are to be congratulated for producing a real gem. Your choice of which of the 30 or so "advanced" (i.e., costing >$60) books on probabilistic sequence analysis will be much more informed if you read this one first.

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    Thursday, 11 February 2010

    [I908.Ebook] Download Structural Stability: Theory Implementation, by Wai-Fah Chen

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    Structural Stability: Theory Implementation, by Wai-Fah Chen

    Structural Stability: Theory and Implementation is a practical work that provides engineers and students in structural engineering or structured mechanics with the background needed to make the transition from fundamental theory to practical design rules and computer implementation. Beginning with the basic principles of structural stability and basic governing equations,Structural Stability is a concise and comprehensive introduction that applies the principles and theory of structural stability (which are the basis for structural steel design) to the solution of practical building frame design problems. Special features include:

    • modern theories of structural stability of members and frames, and a discussion of how these theories may be utilized to provide design rules and calculation techniques for design
    • important governing equations and the classical solutions used in design processes
    • examples of analytical and numerical methods selected as the most useful and practically applicable methods available
    • detailed information on the stability design rules of the 1986 AISC/LRFD Specifications for the design, fabrication, and erection of structural steel for buildings
    • dual units (SI and English) with most of the material presented in a non-dimensional format
    • fully worked examples, end-of-chapter problems, answers to selected problems, and clear illustrations and tables

    Am outstandingly practical resource, Structural Stability offers the reader an understanding of the fundamental principles and theory of structural stability not only in an idealized, perfectly elastic system, but also in an inelastic, imperfect system representative of the actual structural systems encountered in engineering practice.

    • Sales Rank: #1374074 in Books
    • Published on: 1987-04-11
    • Format: Facsimile
    • Original language: English
    • Number of items: 1
    • Dimensions: 8.90" h x 1.10" w x 6.00" l, 1.53 pounds
    • Binding: Paperback
    • 490 pages

    From the Back Cover

    Structural Stability: Theory and Implementation is a practical work that provides engineers and students in structural engineering or structured mechanics with the background needed to make the transition from fundamental theory to practical design rules and computer implementation. Beginning with the basic principles of structural stability and basic governing equations,Structural Stability is a concise and comprehensive introduction that applies the principles and theory of structural stability (which are the basis for structural steel design) to the solution of practical building frame design problems. Special features include:

    • modern theories of structural stability of members and frames, and a discussion of how these theories may be utilized to provide design rules and calculation techniques for design
    • important governing equations and the classical solutions used in design processes
    • examples of analytical and numerical methods selected as the most useful and practically applicable methods available
    • detailed information on the stability design rules of the 1986 AISC/LRFD Specifications for the design, fabrication, and erection of structural steel for buildings
    • dual units (SI and English) with most of the material presented in a non-dimensional format
    • fully worked examples, end-of-chapter problems, answers to selected problems, and clear illustrations and tables

    Am outstandingly practical resource, Structural Stability offers the reader an understanding of the fundamental principles and theory of structural stability not only in an idealized, perfectly elastic system, but also in an inelastic, imperfect system representative of the actual structural systems encountered in engineering practice.

    About the Author

    W. F. Chen teaches at Purdue University and serves on the SSRC Executive Committee and the AISC Committee on Specifications. He has been chairman of several ASCE committees; has authored and co-authored several textbooks and monographs; and is the recipient of seven professional awards.

    �

    E. M. Lui currently teaches at Syracuse University. He is a member of the AISC, the ACI, and the AAM; has published several papers on structural stability; and is the 1986 recipient of the Outstanding Young Man of America Award.

    Most helpful customer reviews

    4 of 4 people found the following review helpful.
    Excellent book on buckling of structures
    By A. I. Haque
    I used this book to prepare for exams in a graduate course in buckling. I highly recommend it to graduate students in structural engineering. Lots of details on methods used to determine buckling loads. A bit weak on computer methods, but those can be found in Chen's book on semi-rigid frames.

    7 of 8 people found the following review helpful.
    Very good explanations for LRFD equations
    By M. A. Adnan
    This book is a must in order to understand how the equations in the AISC LRFD specifications were developed. The book is easy to understand (only basic mechanics of materials, some calculus and ordinary differential equations background is required).

    0 of 0 people found the following review helpful.
    Very theoretical
    By Mike Stancic
    The book itself is very theoretical, but my biggest qualm is that the text has very few examples and does a poor job of explaining some of the finer details. There are practice problems for each chapter and if all you had was this book, you'd never be able to answer them.

    See all 3 customer reviews...

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